Methyl 3,4,5-trimethoxybenzoate CAS NO.1916-07-0

3,4,5-Trimethoxy benzoic acid methyl ester

Production capacity:  50 T/Year

Mol. form and Mol. wt:  C₁₁H₁₄O₅    226.23

Technical data：

Appearance:  white crystalline powder

Purity           %    ≥99.5

Loss on drying    %   ≤ 10

Melting point     ℃   80-84

 Usage: mainly used as medicinal compound intermediate, main material of resist-anxiety medicine named Trimetozine

Storage：keep in a well-closed container.

Packing: circinal-paper barrel with plastic bag inside, N.W. 25kg/bag.                                                                                                                                                                                                                                                                                                                                                                            Chinese name: three, four, five - Methyl benzoate Chinese alias: three oxygen radicals methoxyl benzyl organism impurity H English name: Methyl 3, four, five - trimethoxybenzoate English alias: three, four, five - Trimethoxybenzoic Acid Methyl Ester;EINECS 217-629-3;Methyl tri - O - methylgallate;Three, four, five - Trimethoxybenzoic acid methyl ester;BENZOIC ACID, three, four, five - TRIMETHOXY -, METHYL ESTER;Read more English nickname CAS no. : 1916-07-0 formula: C11H14O5 molecular weight: 226.22600 the precise quality: 226.08400 PSA: LogP 53.99000:1.49900

Physical and chemical properties
Appearance and properties: white to grayish white crystalline powder density: 1.134 g/cm3 melting point: 82-84 ° C (lit.) the boiling point: 274-275 ° C (lit. The flash point) : 274-275 ° C refractive index: vapor pressure: 1.494 0.00538 mmHg at 25 ° C
Safety information
Hs code: 2918990090 WGK Germany: 3 safety instructions: S24: no. 25 rtecs DI0820000 dangerous mark: Xi
Check all production methods and purposes
Production methods


By the gallic acid and dimethyl sulfate methylation reaction.Water, gallic acid, dimethyl sulfate to join reaction pot, add sodium hydroxide solution under 15 to 35 ℃, 40 ℃ stir around half an hour.Add the second batch of dimethyl sulfate, around 40 ℃ to add sodium hydroxide solution pH of 8 to 9.Continue after 1 h of reaction, cooling, filtering, washing, drying, preparation base benzoic acid methyl ester, yield of above 90%.The methylation, the esterification reaction, also can use tetrabutyl ammonium bromide as phase transfer catalyst, in the water and chloroform.The goods tannic acid can also be used as raw material, or by three, four, five - preparation base benzoic acid and methanol esterification to making


use

Is used as pharmaceutical intermediates, anxiolytics sibutramine lamictal, intestines and stomach medicine maleic acid trimebutine, etc. The main raw material.