N-Fluorobenzenesulfonimide CAS NO.133745-75-2

hebei yanxi chemical  co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!

1:Safe shipping (TNT;EMS;FEDEX;DHL;UPS;EUB)

2:Safe payment(Btc;MoneyGram;WU)

3:Safe packing (Paraffin coating; Double aluminum foil bag; Vacuum packaging)

4:Fast delivery (3-10 DAYS fast home delivery service )

5:Best quality (Without any doping, all products are pure)

6:Safety guarantee (we do this business long time ,we know how to disguise let the product through customs)

8:New international transportation system(Pls see the pic,The transportation line reaches every corner of the world)

9:Huge Supply(We have many raw materials and processing centers,Each day can provide dozens of kilogram-hundreds of kilograms of different products.)

10:Low Price(All the products are factory prices it can let you have a bigger profit margin)

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3.best quality 

4.rich experience 

5.support sample

Details

hebei yanxi chemical  co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!

1:Safe shipping (TNT;EMS;FEDEX;DHL;UPS;EUB)

2:Safe payment(Btc;MoneyGram;WU)

3:Safe packing (Paraffin coating; Double aluminum foil bag; Vacuum packaging)

4:Fast delivery (3-10 DAYS fast home delivery service )

5:Best quality (Without any doping, all products are pure)

6:Safety guarantee (we do this business long time ,we know how to disguise let the product through customs)

8:New international transportation system(Pls see the pic,The transportation line reaches every corner of the world)

9:Huge Supply(We have many raw materials and processing centers,Each day can provide dozens of kilogram-hundreds of kilograms of different products.)

10:Low Price(All the products are factory prices it can let you have a bigger profit margin)

Our distribution capabilities include:
● Flexible deliveries, intelligent solutions
● Anything from bulk shipments of thousands of tonnes down to the smallest shipment of packed goods and even samples.
● Bulk – storage and transport of powders and liquids – movement of goods in ships – powders and bulk liquids
● Pharma, feed and food storage to accredited standards
● Segregated materials by business unit and hazard classification
● Temperature controlled storage and transport
● Effective cost control
● Re-packing, drum filling, bagging, ripping and tipping
● Customer delivery KPI's on delivery fulfillment performance

Description:

NFSI is a new, stable and mild fluorination reagent, which can introduce fluorine atoms into the carbonyl o-site of organic molecules, and can monofluorinate electron-rich aromatic compounds, enolsilthers, enollithium salts, etc. Current research focuses on the formation of five-membered ring Nazarov cyclization catalyzed by iron or cobalt, asymmetric catalysis of enantioselective α-fluorination.

Preparation:

There are two main methods for the production of N-fluorodiphenylsulfonamide. The first method is Differding. The specific preparation process is as follows: Dibenzenesulfonimide was dissolved in acetonitrile, sodium fluoride was added, the mixture was cooled to -35℃, and the fluorine nitrogen mixture with a volume ratio of 1:10 was breathed into the mixture for 2 hours, then the nitrogen gas was purred for 2 hours, and white crystals were obtained through filtration, evaporation and recrystallization. The yield was 74%. The other is Wanger method, the specific preparation process is: diphenyl sulfonimide sodium salt dissolved in water/acetonitrile or pure water, cooled into the V(F2):V(N2) = 1:10 fluorine nitrogen mixture, after the reaction is over with nitrogen purgatory reactor, filtered, washed, dried to obtain N-fluorinated diphenyl sulfonamide products, the yield of up to 94%.

Uses:

N-fluorobenzylsulfonamide can be used for palladium-catalyzed enantioselective fluorination of tert-butoxycarbonyl lactones and lactam compounds. It can also be used for electrophilic difluorination of dihalopyridine compounds under the action of butyl lithium, and for direct conversion of alcohols under the action of triphenylphosphine to diphenyl sulfonimide compounds. Stable and easy to handle crystalline material, easy to convert F+ into enolates and negative carbon ions.