Tetramethylpyrazine CAS NO.1124-11-4

hebei yanxi chemical  co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!

1:Safe shipping (TNT;EMS;FEDEX;DHL;UPS;EUB)

2:Safe payment(Btc;MoneyGram;WU)

3:Safe packing (Paraffin coating; Double aluminum foil bag; Vacuum packaging)

4:Fast delivery (3-10 DAYS fast home delivery service )

5:Best quality (Without any doping, all products are pure)

6:Safety guarantee (we do this business long time ,we know how to disguise let the product through customs)

8:New international transportation system(Pls see the pic,The transportation line reaches every corner of the world)

9:Huge Supply(We have many raw materials and processing centers,Each day can provide dozens of kilogram-hundreds of kilograms of different products.)

10:Low Price(All the products are factory prices it can let you have a bigger profit margin)

1.lowest price 

2.good service

3.best quality 

4.rich experience 

5.support sample

Details

hebei yanxi chemical  co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!

1:Safe shipping (TNT;EMS;FEDEX;DHL;UPS;EUB)

2:Safe payment(Btc;MoneyGram;WU)

3:Safe packing (Paraffin coating; Double aluminum foil bag; Vacuum packaging)

4:Fast delivery (3-10 DAYS fast home delivery service )

5:Best quality (Without any doping, all products are pure)

6:Safety guarantee (we do this business long time ,we know how to disguise let the product through customs)

8:New international transportation system(Pls see the pic,The transportation line reaches every corner of the world)

9:Huge Supply(We have many raw materials and processing centers,Each day can provide dozens of kilogram-hundreds of kilograms of different products.)

10:Low Price(All the products are factory prices it can let you have a bigger profit margin)

Our distribution capabilities include:
● Flexible deliveries, intelligent solutions
● Anything from bulk shipments of thousands of tonnes down to the smallest shipment of packed goods and even samples.
● Bulk – storage and transport of powders and liquids – movement of goods in ships – powders and bulk liquids
● Pharma, feed and food storage to accredited standards
● Segregated materials by business unit and hazard classification
● Temperature controlled storage and transport
● Effective cost control
● Re-packing, drum filling, bagging, ripping and tipping
● Customer delivery KPI's on delivery fulfillment performance

Pharmacological action:

Ligustrazine is a bioactive ingredient extracted from ligustrum chuanxiong, a widely used traditional Chinese medicine. It can inhibit platelet aggregation, enhance vasodilation, increase cerebral blood flow, and have neuroprotective effects. Ligustrazine injection has been widely used in the treatment of ischemic stroke, coronary heart disease, diabetic nephropathy and knee osteoarthritis in China. Ligustrazine has also been evaluated clinically for the treatment of pressure ulcers, as a salvage agent for patients with non-Hodgkin's lymphoma, and as a treatment for bronchial asthma and vertebrobasilar dysfunction.

Chemical properties:

white crystal or powder. It has the aroma of beef and pork fat when heated and fermented soy flavor. When diluted to 20mg/kg, it has the flavor of milk chocolate. Boiling point 190℃, melting point 84 ~ 86℃. Soluble in ethanol, most non-volatile oils and propylene glycol, slightly soluble in water. Natural products are found in guava, roast beef, cocoa, coffee, shrimp, etc.

Production method:

butanedione monooxime is formed by condensation of butanone and ethyl nitrite, and then methylmethylpyrazine is obtained by reduction and cyclization. The cyclic reaction products were distilled by steam, and the distillate was cooled, crystallized and filtered to obtain crude tetramethylpyrazine. Water recrystallization and activated carbon decolorization were used for refining. To prepare its hydrochloride, it can be dripped into acetone with an ethanol solution containing 15%-20% hydrogen chloride to form a salt.