4,4'-Diaminodiphenylsulfone CAS NO.80-08-0 CAS NO.80-08-0

hebei yanxi chemical  co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!

Chemical properties:
Dapsone for short DDS, chemical name "4,4 '-diaminodiphenyl sulfone". Molecular formula C12H12N2O2S. Molecular weight 248.3. White or white like crystal or crystalline powder. Odorless, slightly bitter taste. Melting point 176 ~ 181℃. Soluble in ethanol, acetone and excessive dilute hydrochloric acid, insoluble in water. Chemical properties are relatively stable, neutral alkalinity. It can inhibit and kill Bacillus leprae. Toxic reaction: can cause hemolytic anemia and methemoglobinemia. Excessive dose of acute liver damage, exfoliative dermatitis, etc. It is obtained by the reaction of acetanilide with p-aminobenzenesulfonyl chloride, and then the acetylation is removed.

Preparation process:
The molten 4,4 '-dichlorodiphenyl sulfone is driven into the pipeline reactor at a high pressure pump with a flow rate of 140 g/h, while the mixture of ammonia and cuprous chloride with a mass fraction of 25% is driven into the pipeline reactor with a flow rate of 800 g/h (of which cuprous chloride flow rate is 5.6 g/h) by a high pressure pump. The continuous ammonolysis reaction was carried out at 14Mpa pressure and 220℃ temperature, and the residence time of the reaction material in the high-pressure pipeline was 20 minutes. The product was analyzed by liquid chromatography after decompressing by pressure reducing valve. The ammonolysis product contained 0.1% of 4,4' -dichlorodiphenyl sulfone. The material was sent to the recovery device, the excess ammonia was distilled, and the crude 4,4' -diamino-diphenyl sulfone was separated. The crude product was dissolved in hydrochloric acid with 10% mass fraction at 30℃, decolorized with activated carbon, filtered, cooled to below 10℃, adjusted pH value to 2 ~ 2.5 with 10% mass fraction of sodium carbonate solution, centrifuged filtration, and then washed to neutral, and then dried to obtain the finished product with 99.5% purity of 4,4' -diaminodiphenyl sulfone (liquid chromatographic analysis). The total yield was 97.1% (as 4,4 '-dichlorodiphenyl sulfone).