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Norandrostenedione
Name:Norandrostenedione
EINECS:211-995-8
Molecular Formula:C18H24O2
CAS Registry Number:
734-32-7
Synonyms:
(+)-19-Norandrost-4-en-3,17-dione; (+)-19-Norandrost-4-ene-3,17-dione; (+)-Estr-4-ene-3,17-dione; 19-Nor-4-androstenedione; 19-Norandrost-4-ene-3,17-dione; 3,17-Dioxo-19-norandrost-4-ene; NSC 12164; Nordione; d-19-Norandrost-4-ene-3,17-dione;
Molecular Weight:272.38
Density:1.13 g/cm3
Boiling Point:433.4 °C at 760 mmHg
Melting Point:169-172°C
Flash Point:433.4 °C at 760 mmHg
Application:Norethindrone intermediate
standard:Enterprise standard
Assay:98%
Bolandione, also known as 19-norandrostenedione (19-norandrost-4-en-3,17-dione), is a precursor of the anabolic steroid nandrolone. Until 2005, bolandione was available without prescription in United States, where it was marketed as a prohormone, but it is now classified as a Schedule III drug. It is also banned from use in many sports, including the Olympic Games, under the World Anti-Doping Code. Bolandione is readily metabolized to nandrolone after oral administration, but its potency to transactivate the androgen receptor dependent reporter gene expression is 10 times lower as compared to dihydrotestosterone (DHT).
In vivo experiments in castrated rats demonstrated that subcutaneous treatment with bolandione resulted only in a stimulation of the weight of the levator ani muscle, while the prostate and seminal vesicle weights remained completely unaffected. In contrast to its metabolite nandrolone, bolandione highly selectively stimulates the growth of the skeletal muscles but has only weak androgenic properties.
In the early 2000s, contamination of androstenedione products with traces of bolandione caused false positives for doping tests for nandrolone because 19-norandrosterone is a metabolite of both nandrolone and bolandione. In a randomized controlled trial trace contamination of androstenedione with bolandione was sufficient for users of androstenedione to test positive for nandrolone. This detail became less relevant after bolandione and androstenedione were banned by major sporting bodies.
| Density: | 1.13 g/cm3 |
|---|---|
| Melting Point: | 169-172ºC |
| Boiling Point: | 433.4ºC at 760 mmHg |
| Refractive Index: | 1.556 |
| Storage Condition: | Refrigerator |