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8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one CAS NO.5053-06-5
- FOB Price: USD: 500.00-500.00 /Gram Get Latest Price
- Min.Order: 1000 Gram
- Payment Terms: L/C,T/T,
- Available Specifications:
1(1000-10000)Gram
- Product Details
Keywords
- 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
- EINECS 225-751-3; Fenspiridum [INN-Latin]; Fenspirida [INN-Spanish]; Respiride; Viarespan; 8-phenethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; fenspiride; Fenspiride [INN] more
- 5053-06-5
Quick Details
- ProName: 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro...
- CasNo: 5053-06-5
- Molecular Formula: C15H20N2O2
- Appearance: appearance White powder
- Application: Widely used in cosmetics, medicine, be...
- DeliveryTime: 3day
- PackAge: 1000 g/aluminum foil bag
- Port: tianjin china
- ProductionCapacity: 10 Metric Ton/Month
- Purity: 99.5（%）
- Storage: Dry and ventilated
- Transportation: shipping
- LimitNum: 1000 Gram
- Moisture Content: PH (0.1% aqueous solution) : 6.0 ~ 7.5
- Impurity: Protein: 0.1% or less
- Light transmittance (0.1% aqueous solution) : 0.1% or greater: Light transmittance (0.1% aqueous solu...
Superiority
chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!The quality of our products meet all international standards, the German advanced equipment are imported equipment two laboratories, individual, on scale management concept, our aim is;With the highest quality. The lowest price. The best service to meet the new and old customers around the world, develop together for a better future!
Details
Keywords
Neural mechanisms contribute to control of mucus secretion in the airways. Fenspiride is a non-steroidal antiinflammatory agent which has a variety of actions, including inhibition of neurogenic bronchoconstriction. The effect of fenspiride on neurally-mediated mucus secretion was investigated in vitro in electrically-stimulated ferret trachea, using(35)SO(4)as a mucus marker. Cholinergic secretory responses were isolated using adrenoceptor and tachykinin receptor antagonists. Tachykinin responses were isolated using cholinoceptor and adrenoceptor antagonists. Electrical stimulation increased cholinergic secretion by;90% and tachykininergic secretion by;40%. Fenspiride (1 microM-1 mM) tended to inhibit cholinergic secretion in a concentration-dependent manner, although only at 1 mM was inhibition (by 87%) significant. Inhibition by fenspiride of tachykininergic secretion was not concentration-dependent, and again significant inhibition (by 85%) was only at 1 mM. Inhibition was not due to loss of tissue viability, as assessed by restitution of secretory response after washout. Fenspiride also inhibited secretion induced by acetylcholine, but did not inhibit substance P-induced secretion. Histamine receptor antagonists increased basal secretion by 164%, whereas fenspiride did not affect basal secretion. We conclude that, in ferret trachea in vitro, fenspiride inhibits neurally-mediated mucus secretion, with antimuscarinic action the most plausible mechanism of action, but not necessarily the only mechanism. 
